Enantioselective Haloetherification by Asymmetric Opening of meso-Halonium Ions

被引：151

作者：

Hennecke, Ulrich ^{[1
]}

Mueller, Christian H. ^{[1
]}

Froehlich, Roland ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

关键词：

BRONSTED ACID; HALOCYCLIZATION; BROMOLACTONIZATION; CATALYSIS; METAL; IODOCYCLIZATION; THIIRANIUM; COMPLEXES; BROMONIUM; SALTS;

D O I：

10.1021/ol1028805

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to enantioselective haloetherification reactions via desymmetrization of in situ-generated meso-halonium ions is described. The combination of N-haloamides as a halogen source and sodium salts of chiral phosphoric acids as catalysts can be used for the cyclization of symmetrical ene-diol substrates, yielding the haloetherification products under practical conditions in enantioenriched form.

引用

页码：860 / 863

页数：4

共 46 条

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