Metal-catalyzed enantioselective allylation in asymmetric synthesis

被引：1264

作者：

Lu, Zhan ^{[2
]}

Ma, Shengming ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synthesis, Hangzhou 310027, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 02期

关键词：

allylation; asymmetric catalysis; chiral ligands; natural products; regioselectivity;

D O I：

10.1002/anie.200605113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-catalyzed enantioselective allylation, which involves the substitution of allylic metal intermediates with a diverse range of different nucleophiles or SN2′-type allylic substitution, leads to the formation of C-H, -C, -O, -N, S, and other bonds with very high levels of asymmetric induction. The reaction may tolerate a broad range of functional groups and has been applied successfully to the synthesis of many natural products and new chiral compounds. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：258 / 297

页数：40

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