Controlled gelation temperature, pore diameter and degradation of a highly porous chitosan-based hydrogel

被引：98

作者：

Dang, Qi Feng ^{[1
]}

Yan, Jing Quan ^{[2
]}

Li, Jing Jing ^{[1
]}

Cheng, Xiao Jie ^{[1
]}

Liu, Cheng Sheng ^{[1
]}

Chen, Xi Guang ^{[1
]}

机构：

[1] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

[2] Seabeau Cosmet Co Ltd, Engineer Res & Dev Ctr, Qingdao 266111, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2011年 / 83卷 / 01期

关键词：

Highly porous hydrogel; Gelation temperature; Pore diameter; Degradation behavior; BETA-GLYCEROPHOSPHATE; THERMOSENSITIVE HYDROGEL; RHEOLOGICAL CHARACTERIZATION; SOLUTION BEHAVIOR; DELIVERY-SYSTEM; DRUGS; GELS; REGENERATION; CELLS;

D O I：

10.1016/j.carbpol.2010.07.038

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

In this study, highly porous chitosan-alpha,beta-glycerophosphate hydrogels were prepared by changing the chitosan/alpha,beta-glycerophosphate ratio. The gelation temperatures of these gels determined from rheological analysis indicated that the gelation temperature decreased by increasing alpha,beta-glycerophosphate content. The chemical structures and morphology of the hydrogels were examined by FTIR and SEM, respectively. The SEM images showed a highly porous 3D chitosan-alpha,beta-glycerophosphate hydrogel structure with interconnected pores and the pore diameters depended on the chitosan/alpha,beta-glycerophosphate ratio. The swelling and degradation experiments indicated that the degradation behaviors of these hydrogels via bulk erosion relied heavily on the chitosan/alpha,beta-glycerophosphate ratio. This study suggested that the gelation temperature, pore diameter and degradation behaviors of chitosan-based porous hydrogels can be controlled by changing the ratio of chitosan and alpha,beta-glycerophosphate. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：171 / 178

页数：8

共 30 条

[1]

Novel pH, ion sensitive polyampholyte gels based on carboxymethyl chitosan and gelatin [J].