The light and dark sides of intestinal intraepithelial lymphocytes

被引：488

作者：

Cheroutre, Hilde ^{[1
]}

Lambolez, Florence ^{[1
]}

Mucida, Daniel ^{[2
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Lab Dev Immunol, La Jolla, CA 92037 USA

[2] Rockefeller Univ, Lab Mucosal Immunol, New York, NY 10065 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DELTA-T-CELLS; INFLAMMATORY-BOWEL-DISEASE; LISTERIA-MONOCYTOGENES INFECTION; RECENT THYMIC EMIGRANTS; RECEPTOR-GAMMA-DELTA; CELIAC-DISEASE; RETINOIC-ACID; TGF-BETA; EPITHELIAL-CELLS; ALPHA-BETA;

D O I：

10.1038/nri3007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form one of the main branches of the immune system. As IELs are located at this critical interface between the core of the body and the outside environment, they must balance protective immunity with an ability to safeguard the integrity of the epithelial barrier: failure to do so would compromise homeostasis of the organism. In this Review, we address how the unique development and functions of intestinal IELs allow them to achieve this balance.

引用

页码：445 / 456

页数：12

共 178 条

[1] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078

[2] T-cell recruitment to the intestinal mucosa [J].

Agace, William W. .

TRENDS IN IMMUNOLOGY, 2008, 29 (11) :514-522

[3] Viral mechanisms of immune evasion [J].

Alcami, A ;

Koszinowski, UH .

IMMUNOLOGY TODAY, 2000, 21 (09) :447-455

[4] Distribution of alpha(4)beta(7) and alpha(E)beta(7) integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes [J].

Andrew, DP ;

Rott, LS ;

Kilshaw, PJ ;

Butcher, EC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :897-905

[5] Delineation of the function of a major γδ T cell subset during infection [J].

Andrew, EM ;

Newton, DJ ;

Dalton, JE ;

Egan, CE ;

Goodwin, SJ ;

Tramonti, D ;

Scott, P ;

Carding, SR .

JOURNAL OF IMMUNOLOGY, 2005, 175 (03) :1741-1750

[6] Essential role of CD8 palmitoylation in CD8 coreceptor function [J].

Arcaro, A ;

Grégoire, C ;

Boucheron, N ;

Stotz, S ;

Palmer, E ;

Malissen, B ;

Luescher, IF .

JOURNAL OF IMMUNOLOGY, 2000, 165 (04) :2068-2076

[7] Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph [J].

Arstila, T ;

Arstila, TP ;

Calbo, S ;

Selz, F ;

Malassis-Seris, M ;

Vassalli, P ;

Kourilsky, P ;

Guy-Grand, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :823-834

[8] EXTRATHYMIC ORIGIN OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES BEARING T-CELL ANTIGEN RECEPTOR-GAMMA-DELTA [J].

BANDEIRA, A ;

ITOHARA, S ;

BONNEVILLE, M ;

BURLENDEFRANOUX, O ;

MOTASANTOS, T ;

COUTINHO, A ;

TONEGAWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) :43-47

[9] Inhibition of TGF-β signaling by IL-15:: A new role for IL-15 in the loss of immune homeostasis in celiac disease [J].

Benahmed, Melika ;

Meresse, Bertrand ;

Arnulf, Bertrand ;

Barbe, Ullah ;

Mention, Jean-Jacques ;

Verkarre, Virginie ;

Allez, Matthieu ;

Cellier, Christophe ;

Hermine, Olivier ;

Cerf-Bensussan, Nadine .

GASTROENTEROLOGY, 2007, 132 (03) :994-1008

[10] Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease [J].

Bhagat, Govind ;

Naiyer, Afzal J. ;

Shah, Jayesh G. ;

Harper, Jason ;

Jabri, Bana ;

Wang, Timothy C. ;

Green, Peter H. R. ;

Manavalan, John S. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :281-293

← 1 2 3 4 5 6 7 8 9 10 →