Acid-catalyzed addition of N-hydroxyurea to 1-aryl alcohol derivatives:: A new synthesis of Zileuton

被引：5

作者：

Copp, RR ^{[1
]}

Fohey, BT ^{[1
]}

Lannoye, G ^{[1
]}

机构：

[1] Abbott Labs, Specialty Prod Div, N Chicago, IL 60064 USA

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 20期

关键词：

alkylation; hydroxamic acids and derivatives; regioselection;

D O I：

10.1081/SCC-100105880

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient synthesis of Zileuton is described in which the key step involves a site-specific alkylation of hydroxyurea under acid catalysis. Various aryl alcohol electrophiles were tested and the reaction was found to be highly substrate-specific, favoring benzothiophene and benzofuran-based alcohols.

引用

页码：3081 / 3086

页数：6

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