RESOLUTION OF HYDROXYUREAS

被引：10

作者：

GARIGIPATI, RS

SORENSON, ME

ERHARD, KF

ADAMS, JL

机构：

[1] Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19046

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)73875-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic hydroxyureas can be efficiently resolved on a preparative scale using (4S)-4-benzyl-2-oxazolidinone-3-carbonyl chloride 3. The resulting carbamates can be separated by chromatography and hydrolysis of these diastereomers yields enantiomerically pure hydroxyureas.

引用

收藏

页码：5537 / 5540

页数：4

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