Charge interactions do the job: A combined statistical and combinatorial approach to finding artificial receptors for binding tetrapeptides in water

被引：32

作者：

Schmuck, C ^{[1
]}

Heil, M

Scheiber, J

Baumann, K

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Wurzburg, Inst Pharm & Lebensmittelchem, D-97074 Wurzburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

combinatorial chemistry; receptors; structure-activity relationships; supramolecular chemistry;

D O I：

10.1002/anie.200501812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Statistical QSAR analysis (QSAR = quantitative structure-activity relationship) was applied to quantitative experimental screening data of a small, but focused, combinatorial library to identify potent receptors (1, see scheme). Analysis showed that no receptors with better efficiency would be expected, even if a 15-times larger library was used. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7208 / 7212

页数：5

共 90 条

[1] Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation [J].

Albert, JS ;

Peczuh, MW ;

Hamilton, AD .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (08) :1455-1467

[2]

[Anonymous], [No title captured]

[3]

[Anonymous], 1992, INTERMOLECULAR SURFA

[4]

[Anonymous], 1997, SUPRAMOLECULAR CHEM

[5] Combinatorial libraries of diamidopyridine-derived 'tweezer' receptors and sequence selective binding of peptides [J].

Arienzo, R ;

Kilburn, JD .

TETRAHEDRON, 2002, 58 (04) :711-719

[6] A systematic evaluation of the benefits and hazards of variable selection in latent variable regression. Part II. Practical applications [J].

Baumann, K ;

von Korff, M ;

Albert, H .

JOURNAL OF CHEMOMETRICS, 2002, 16 (07) :351-360

[7] A systematic evaluation of the benefits and hazards of variable selection in latent variable regression. Part I. Search algorithm, theory and simulations [J].

Baumann, K ;

Albert, H ;

von Korff, M .

JOURNAL OF CHEMOMETRICS, 2002, 16 (07) :339-350

[8] Molecular recognition of anions by synthetic receptors [J].

Beer, PD ;

Schmitt, P .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (04) :475-482

[9] Abiotic guanidinium containing receptors for anionic species [J].

Best, MD ;

Tobey, SL ;

Anslyn, EV .

COORDINATION CHEMISTRY REVIEWS, 2003, 240 (1-2) :3-15

[10]

Bohm HJ, 1996, ANGEW CHEM INT EDIT, V35, P2589

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