Charge interactions do the job: A combined statistical and combinatorial approach to finding artificial receptors for binding tetrapeptides in water

被引：32

作者：

Schmuck, C ^{[1
]}

Heil, M

Scheiber, J

Baumann, K

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Wurzburg, Inst Pharm & Lebensmittelchem, D-97074 Wurzburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

combinatorial chemistry; receptors; structure-activity relationships; supramolecular chemistry;

D O I：

10.1002/anie.200501812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Statistical QSAR analysis (QSAR = quantitative structure-activity relationship) was applied to quantitative experimental screening data of a small, but focused, combinatorial library to identify potent receptors (1, see scheme). Analysis showed that no receptors with better efficiency would be expected, even if a 15-times larger library was used. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7208 / 7212

页数：5

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