European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans

被引：198

作者：

Marcus, Gregory M. ^{[1
]}

Alonso, Alvaro ^{[4
]}

Peralta, Carmen A. ^{[2
]}

Lettre, Guillaume ^{[5
]}

Vittinghoff, Eric ^{[3
]}

Lubitz, Steven A. ^{[6
,8
]}

Fox, Ervin R. ^{[9
]}

Levitzky, Yamini S. ^{[10
]}

Mehra, Reena ^{[11
,12
]}

Kerr, Kathleen F. ^{[13
]}

Deo, Rajat ^{[16
]}

Sotoodehnia, Nona ^{[14
]}

Akylbekova, Meggie ^{[9
]}

Ellinor, Patrick T. ^{[6
,7
]}

Paltoo, Dina N. ^{[17
]}

Soliman, Elsayed Z. ^{[18
]}

Benjamin, Emelia J. ^{[19
,20
,21
]}

Heckbert, Susan R. ^{[15
]}

机构：

[1] Univ Calif San Francisco, Div Cardiol, Electrophysiol Sect, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Div Nephrol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[5] Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada

[6] Harvard Univ, Sch Med, Cardiovasc Res Ctr, Boston, MA USA

[7] Harvard Univ, Sch Med, Cardiac Arrhythmia Serv, Boston, MA USA

[8] Harvard Univ, Brigham & Womens Hosp, Massachusetts Gen Hosp, Div Prevent Med,Med Sch, Boston, MA 02115 USA

[9] Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS USA

[10] Case Western Reserve Univ, Heart & Vasc Ctr, Div Cardiol, Cleveland, OH 44106 USA

[11] Case Western Reserve Univ, Ctr Clin Invest, Cleveland, OH 44106 USA

[12] Case Western Reserve Univ, Div Pulm Crit Care & Sleep Med, Cleveland, OH 44106 USA

[13] Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA

[14] Univ Washington, Dept Med, Div Cardiol, Seattle, WA USA

[15] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[16] Univ Penn, Electrophysiol Sect, Div Cardiovasc Med, Philadelphia, PA 19104 USA

[17] Natl Heart Blood & Lung Inst, NIH, DHHS, Bethesda, MD USA

[18] Wake Forest Univ, Bowman Gray Sch Med, Epidemiol Cardiol Res Ctr, Dept Epidemiol & Prevent, Winston Salem, NC USA

[19] Boston Univ, Sch Med, Evans Dept Med, Div Cardiol & Prevent Med, Boston, MA 02118 USA

[20] Boston Univ, Sch Med, Evans Dept Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[21] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

来源：

CIRCULATION | 2010年 / 122卷 / 20期

基金：

美国国家卫生研究院;

关键词：

ancestry; African Americans; atrial fibrillation; genetics; HEART-FAILURE; LOCUS; EPIDEMIOLOGY; HYPERTENSION; PREVALENCE; MANAGEMENT; INFERENCE; MUTATION; HISTORY; DISEASE;

D O I：

10.1161/CIRCULATIONAHA.110.958306

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic or environmental factors. Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF. Methods and Results-We studied whites (n=4543) and African Americans (n=822) in the Cardiovascular Health Study (CHS) and whites (n=10 902) and African Americans (n=3517) in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517). Percent European ancestry in African Americans was estimated with 1747 ancestry informative markers from the Illumina custom ITMAT-Broad-CARe array. Among African Americans without baseline AF, 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF. A meta-analysis from the 2 studies revealed that every 10% increase in European ancestry increased the risk of AF by 13% (hazard ratio, 1.13; 95% confidence interval, 1.03 to 1.23; P=0.007). After adjustment for potential confounders, European ancestry remained a predictor of incident AF in each cohort alone, with a combined estimated hazard ratio for each 10% increase in European ancestry of 1.17 (95% confidence interval, 1.07 to 1.29; P=0.001). A second analysis using 3192 ancestry informative markers from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results. Conclusions-European ancestry predicted risk of incident AF. Our study suggests that investigating genetic variants contributing to differential AF risk in individuals of African versus European ancestry will be informative. (Circulation. 2010; 122: 2009-2015.)

引用

页码：2009 / 2015

页数：7

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