Synthesis of benzoyl and dodecanoyl derivatives from protected carbohydrates under focused microwave irradiation

A microwave assisted phase transfer catalyzed transesterification in basic medium with methyl benzoate was studied for several carbohydrates. Small amounts of DMF were necessary to provide good yields (96-76%) within 15 minutes. This method was extended to the synthesis of dodecanoyl derivatives with 63-100% global yields within 15 to 30 minutes. Rate enhancements when compared to conventional heating in the same conditions and specific microwave activation were mostly evidenced when fatty compounds (less reactive) were involved. (C) 1998 Elsevier Science Ltd. All rights reserved.