Questioning the paradigm of metal complex promoted phosphodiester hydrolysis:: [Mo7O24]6- polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

被引：64

作者：

Cartuyvels, Els ^{[1
]}

Absillis, Gregory ^{[1
]}

Parac-Vogt, Tatjana N. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 01期

关键词：

D O I：

10.1039/b714860g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl) phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24](6-) with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.

引用

页码：85 / 87

页数：3

共 32 条

[1] Phosphate ester hydrolysis by hydroxo complexes of trivalent lanthanides stabilized by 4-imidazolecarboxylate [J].

Aguilar-Perez, Francisco ;

Gomez-Tagle, Paola ;

Collado-Fregoso, Elisa ;

Yatsimirsky, Anatoly K. .

INORGANIC CHEMISTRY, 2006, 45 (23) :9502-9517

[2] CO(III) COMPLEX PROMOTED HYDROLYSIS OF PHOSPHATE DIESTERS - COMPARISON IN REACTIVITY OF RIGID CIS-DIAQUOTETRAAZACOBALT(III) COMPLEXES [J].

CHIN, J ;

BANASZCZYK, M ;

JUBIAN, V ;

ZOU, X .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (01) :186-190

[3]

Cruywagen JJ, 2000, ADV INORG CHEM, V49, P127

[4] Molybdenum(VI) equilibria in different ionic media. Formation constants and thermodynamic quantities [J].

Cruywagen, JJ ;

Draaijer, AG ;

Heyns, JBB ;

Rohwer, EA .

INORGANICA CHIMICA ACTA, 2002, 331 (01) :322-329

[5] Efficient phosphodiester binding and cleavage by a ZnII complex combining hydrogen-bonding interactions and double lewis acid activation [J].

Feng, Guoqiang ;

Natale, Daniela ;

Prabaharan, Ravi ;

Mareque-Rivas, Juan C. ;

Williams, Nicholas H. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (42) :7056-7059

[6] CATALYSIS BY POLYOXOMETALATES .1. SUPPORTED POLYOXOANIONS OF THE KEGGIN STRUCTURE - SPECTROSCOPIC STUDY (IR, RAMAN, UV) OF SOLUTIONS USED FOR IMPREGNATION [J].

FOURNIER, M ;

THOUVENOT, R ;

ROCCHICCIOLIDELTCHEFF, C .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1991, 87 (02) :349-356

[7]

Fritsky IO, 2000, ANGEW CHEM INT EDIT, V39, P3255, DOI 10.1002/1521-3773(20000915)39:18<3255::AID-ANIE3255>3.0.CO

[8]

2-7

[9]

GERALDES CFG, 1986, INORG CHIM ACTA, V28, P319

[10] Cytotoxic effects of novel polyoxotungstates and a platinum compound on human cancer cell lines [J].

Gerth, HUV ;

Rompel, A ;

Krebs, B ;

Boos, J ;

Lanvers-Kaminsky, C .

ANTI-CANCER DRUGS, 2005, 16 (01) :101-106

← 1 2 3 4 →