Conjugation of two complementary anti-cancer drugs confers molecular hydrogels as a co-delivery system

被引:112
作者
Mao, Lina [1 ,2 ]
Wang, Huaimin [1 ,2 ]
Tan, Ming [1 ,2 ]
Ou, Lailiang [1 ,2 ]
Kong, Deling [1 ,2 ]
Yang, Zhimou [1 ,2 ]
机构
[1] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[2] Nankai Univ, Key Lab Bioact Mat, Minist Educ, Coll Life Sci, Tianjin 300071, Peoples R China
关键词
DEXAMETHASONE; VANCOMYCIN; PACLITAXEL; PRODRUGS;
D O I
10.1039/c1cc16250k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We reported in this communication on the first example of a molecular hydrogel system based on two complementary anticancer drugs for chemotherapy.
引用
收藏
页码:395 / 397
页数:3
相关论文
共 32 条
[1]   Biotin-amino acid conjugates: An approach toward self-assembled hydrogelation [J].
Bhuniya, S ;
Park, SM ;
Kim, BH .
ORGANIC LETTERS, 2005, 7 (09) :1741-1744
[2]   (S)-(+)-Ibuprofen-based hydrogelators:: an approach toward anti-inflammatory drug delivery [J].
Bhuniya, Sankarprasad ;
Seo, Young Jun ;
Kim, Byeang Hyean .
TETRAHEDRON LETTERS, 2006, 47 (40) :7153-7156
[3]  
Cherif-Cheikh R., 1998, Proc. Int'l. Symp. Control. Release Bioact. Mater, V25, P798
[4]   Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative [J].
Gao, Yuan ;
Kuang, Yi ;
Guo, Zu-Feng ;
Guo, Zhihong ;
Krauss, Isaac J. ;
Xu, Bing .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (38) :13576-13577
[5]   Taxol-loaded block copolymer nanospheres composed of methoxy poly(ethylene glycol) and poly(ε-caprolactone) as novel anticancer drug carriers [J].
Kim, SY ;
Lee, YM .
BIOMATERIALS, 2001, 22 (13) :1697-1704
[6]  
KRIS MG, 1987, CANCER-AM CANCER SOC, V60, P2816, DOI 10.1002/1097-0142(19871201)60:11<2816::AID-CNCR2820601137>3.0.CO
[7]  
2-7
[8]   Design and optimization of 20-O-linked camptothecin glycoconjugates as anticancer agents [J].
Lerchen, HG ;
Baumgarten, J ;
von dem Bruch, K ;
Lehmann, TE ;
Sperzel, M ;
Kempka, G ;
Fiebig, HH .
JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (24) :4186-4195
[9]   Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent [J].
Li, Xinming ;
Li, Jiayang ;
Gao, Yuan ;
Kuang, Yi ;
Shi, Junfeng ;
Xu, Bing .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (50) :17707-17709
[10]   Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate [J].
Luo, Y ;
Prestwich, GD .
BIOCONJUGATE CHEMISTRY, 1999, 10 (05) :755-763