Conformational changes and disease - serpins, prions and Alzheimer's

被引：208

作者：

Carrell, RW ^{[1
]}

Gooptu, B ^{[1
]}

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0959-440X(98)80101-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition, The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.

引用

页码：799 / 809

页数：11

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