Protein-cross-linked polymeric materials through site-selective bioconjugation

被引：62

作者：

Esser-Kahn, Aaron P. ^{[1
,2
]}

Francis, Matthew B. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期

关键词：

bioconjugation; gels; hybrid materials; polymers; proteins;

D O I：

10.1002/anie.200705564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Creating a greener future: A strategy for creating hybrid materials of polymers and proteins relies on orthogonal reactions to activate the N and C termini of a protein concurrently. The protein is then used to cross-link polymer chains and create a hydrogel (see picture). A model hybrid hydrogel containing enhanced green fluorescent protein is both biodegradable and responsive to changes in pH and temperature. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3751 / 3754

页数：4

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