Protein-cross-linked polymeric materials through site-selective bioconjugation

被引：62

作者：

Esser-Kahn, Aaron P. ^{[1
,2
]}

Francis, Matthew B. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期

关键词：

bioconjugation; gels; hybrid materials; polymers; proteins;

D O I：

10.1002/anie.200705564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Creating a greener future: A strategy for creating hybrid materials of polymers and proteins relies on orthogonal reactions to activate the N and C termini of a protein concurrently. The protein is then used to cross-link polymer chains and create a hydrogel (see picture). A model hybrid hydrogel containing enhanced green fluorescent protein is both biodegradable and responsive to changes in pH and temperature. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3751 / 3754

页数：4

共 29 条

[11]

Lee SJ, 1996, J MOL RECOGNIT, V9, P549, DOI 10.1002/(SICI)1099-1352(199634/12)9:5/6<549::AID-JMR299>3.0.CO

[12]

2-C

[13] A reversibly antigen-responsive hydrogel [J].

Miyata, T ;

Asami, N ;

Uragami, T .

NATURE, 1999, 399 (6738) :766-769

[14] Expressed protein ligation: A general method for protein engineering [J].

Muir, TW ;

Sondhi, D ;

Cole, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6705-6710

[15]

Murphy W. L., 2007, ANGEW CHEM, V119, P3126

[16] Dynamic hydrogels: Translating a protein conformational change into macroscopic motion [J].

Murphy, William L. ;

Dillmore, W. Shannon ;

Modica, Justin ;

Mrksich, Milan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (17) :3066-3069

[17] Thermal stability of chemically denatured green fluorescent protein (GFP) -: A preliminary study [J].

Nagy, A ;

Málnási-Csizmadia, A ;

Somogyi, B ;

Lorinczy, D .

THERMOCHIMICA ACTA, 2004, 410 (1-2) :161-163

[18] Versatile glycoblotting nanoparticles for high-throughput protein glycomics [J].

Niikura, K ;

Kamitani, R ;

Kurogochi, M ;

Uematsu, R ;

Shinohara, Y ;

Nakagawa, H ;

Deguchi, K ;

Monde, K ;

Kondo, H ;

Nishimura, SI .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (13) :3825-3834

[19]

Nishimura S.-I., 2005, ANGEW CHEMIE, V117, P93, DOI 10.1002/ange.200461685

[20] High-throughput protein glycomics: Combined use of chemoselective glycoblotting and MALDI-TOF/TOF mass spectrometry [J].

Nishimura, SI ;

Niikura, K ;

Kurogochi, M ;

Matsushita, T ;

Fumoto, M ;

Hinou, H ;

Kamitani, R ;

Nakagawa, H ;

Deguchi, K ;

Miura, N ;

Monde, K ;

Kondo, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (01) :91-96

← 1 2 3 →