Structures of cytotoxic bicyclic hexapeptides, RA-XIX, -XX, -XXI, and -XXII, from Rubia cordifolia L.

被引：20

作者：

Lee, Ji-Ean ^{[1
]}

Hitotsuyanagi, Yukio ^{[1
]}

Takeya, Koichi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

TETRAHEDRON | 2008年 / 64卷 / 18期

关键词：

RA-XIX; RA-XX; RA-XXI; RA-XXII; Rubia cordifolia; bouvardin; cytotoxicity;

D O I：

10.1016/j.tet.2008.01.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel bicyclic hexapeptides, RA-XIX, -XX, -XXI, and -XXII, were isolated from the roots of Rubia cordifolia L. The structures of RA-XIX and RA-XX were established by semisynthesis from a cycloisodityrosine, derived from previously reported RA-VII, and those of RA-XXI and RA-XXII by chemical correlation with RA-XX and previously reported RA-VIII, respectively. The IC(50) values of these new peptides against P-388 leukemia cells were 0.013-0.63 mu g/mL. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4117 / 4125

页数：9

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