Three-dimensional MRI of coronary arteries using an intravascular contrast agent

被引:85
作者
Li, DB
Dolan, RP
Walovitch, RC
Lauffer, RB
机构
[1] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
[2] EPIX Med Inc, Cambridge, MA USA
关键词
MRI; coronary vessels; contrast agents; animal studies;
D O I
10.1002/mrm.1910390621
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To assess the effectiveness of an intravascular contrast agent, MS-325, for enhancing the vascular signal in coronary MR angiograms, six minipigs were studied using a three-dimensional, gradient-echo sequence with retrospective respiratory gating. To suppress the myocardial signal, preparatory RF pulses were applied before data acquisition. With the administration of MS-325, the blood signal-to-noise ratio increased by 97-276%, depending on the region of interest in which the blood signal was measured and the precontrast imaging sequence structures. The blood/myocardium contrast-to-noise ratio also significantly increased. High-resolution images (0.58 x 0.58 x 1 mm(3)) obtained from postmortem pig hearts demonstrated the potential delineation of coronary arteries with MS-325. In conclusion, this study supports further evaluation of the utility of MS-325 in improving coronary MR angiography in humans.
引用
收藏
页码:1014 / 1018
页数:5
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