High mobility group proteins of the plant HMGB family: Dynamic chromatin modulators

被引:46
作者
Grasser, Klaus D. [1 ]
Launholt, Dorte [1 ]
Grasser, Marion [1 ]
机构
[1] Aalborg Univ, Dept Life Sci, DK-9000 Aalborg, Denmark
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2007年 / 1769卷 / 5-6期
关键词
plant chromatin; high mobility group (HMG) protein; transcription; DNA-binding; architectural factor; nucleoprotein complex;
D O I
10.1016/j.bbaexp.2006.12.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In plants, the chromosomal high mobility group (HMG) proteins of the HMGB family typically contain a central HMG-box DNA-binding domain that is flanked by a basic N-terminal and an acidic C-terminal domain. The HMGB proteins are abundant and highly mobile proteins in the cell nucleus that influence chromatin structure and enhance the accessibility of binding sites to regulatory factors. Due to their remarkable DNA bending activity, HMGB proteins can increase the structural flexibility of DNA, promoting the assembly of nucleoprotein complexes that control DNA-dependent processes including transcription. Therefore, members of the HMGB family act as versatile modulators of chromatin function. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:346 / 357
页数:12
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