WNT5A is epigenetically silenced in hematologic malignancies and inhibits leukemia cell growth as a tumor suppressor

被引:48
作者
Ying, Jianming [1 ]
Li, Hongyu [1 ]
Chen, Yun-Wen [1 ]
Srivastava, Gopesh [1 ]
Gao, Zifen [1 ]
Tao, Qian [1 ]
机构
[1] Chinese Univ Hong Kong, Honh Kong Canc Inst, Li Ka Shing Inst Hlth Sci, Dept Clin Oncol,State Key Lab Oncol S China, Sha Tin 100083, Peoples R China
关键词
D O I
10.1182/blood-2007-06-094870
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4130 / 4132
页数:3
相关论文
共 10 条
[1]   The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca2+ pathway to antagonize Wnt/β-catenin signaling [J].
Ishitani, T ;
Kishida, S ;
Hyodo-Miura, J ;
Ueno, N ;
Yasuda, J ;
Waterman, M ;
Shibuya, H ;
Moon, RT ;
Ninomiya-Tsuji, J ;
Matsumoto, K .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (01) :131-139
[2]   The fundamental role of epigenetic events in cancer [J].
Jones, PA ;
Baylin, SB .
NATURE REVIEWS GENETICS, 2002, 3 (06) :415-428
[3]   Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue [J].
Liang, HL ;
Chen, Q ;
Coles, AH ;
Anderson, SJ ;
Pihan, G ;
Bradley, A ;
Gerstein, R ;
Jurecic, R ;
Jones, SN .
CANCER CELL, 2003, 4 (05) :349-360
[4]   The Wnt signaling pathway in development and disease [J].
Logan, CY ;
Nusse, R .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :781-810
[5]   Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context [J].
Mikels, AJ ;
Nusse, R .
PLOS BIOLOGY, 2006, 4 (04) :570-582
[6]   Wnt signalling in stem cells and cancer [J].
Reya, T ;
Clevers, H .
NATURE, 2005, 434 (7035) :843-850
[7]   RETRACTED: Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia (Retracted article. See vol. 120, pg. 3625, 2012) [J].
Roman-Gomez, Jose ;
Cordeu, Lucia ;
Agirre, Xabier ;
Jimenez-Velasco, Antonio ;
Jose-Eneriz, Edurne San ;
Garate, Leire ;
Calasanz, Maria Jose ;
Heiniger, Anabel ;
Torres, Antonio ;
Prosper, Felipe .
BLOOD, 2007, 109 (08) :3462-3469
[8]   Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation [J].
Topol, L ;
Jiang, XY ;
Choi, H ;
Garrett-Beal, L ;
Carolan, PJ ;
Yang, YZ .
JOURNAL OF CELL BIOLOGY, 2003, 162 (05) :899-908
[9]   DIFFERENTIAL TRANSFORMATION OF MAMMARY EPITHELIAL-CELLS BY WNT GENES [J].
WONG, GT ;
GAVIN, BJ ;
MCMAHON, AP .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) :6278-6286
[10]   The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors [J].
Ying, JM ;
Srivastava, G ;
Hsieh, WS ;
Gao, ZF ;
Murray, P ;
Liao, SK ;
Ambinder, R ;
Tao, Q .
CLINICAL CANCER RESEARCH, 2005, 11 (18) :6442-6449