Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus

被引：46

作者：

Crameri, Gary ^{[1
]}

Durr, Peter A. ^{[1
]}

Klein, Reuben ^{[1
]}

Foord, Adam ^{[1
]}

Yu, Meng ^{[1
]}

Riddell, Sarah ^{[1
]}

Haining, Jessica ^{[1
]}

Johnson, Dayna ^{[1
]}

Hemida, Maged G. ^{[2
,3
]}

Barr, Jennifer ^{[1
]}

Peiris, Malik ^{[4
]}

Middleton, Deborah ^{[1
]}

Wang, Lin-Fa ^{[5
]}

机构：

[1] CSIRO Australian Anim Hlth Lab, 5 Portarlington Rd, Geelong, Vic 3220, Australia

[2] Kafrelsheikh Univ, Kafr Al Sheikh, Egypt

[3] King Faisal Univ, Al Hufuf, Saudi Arabia

[4] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[5] Duke Natl Univ Singapore, Sch Med, Singapore, Singapore

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

DROMEDARY CAMELS; MERS-COV;

D O I：

10.3201/eid2206.160007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.

引用

页码：1071 / 1074

页数：4

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