Molecular signature of human embryonic stem cells and its comparison with the mouse

被引：357

作者：

Sato, N

Sanjuan, IM

Heke, M

Uchida, M

Naef, F

Brivanlou, AH

机构：

[1] Rockefeller Univ, Lab Vertebrate Mol Embryol, New York, NY 10021 USA

[2] Rockefeller Univ, Phys Math Lab, New York, NY 10021 USA

来源：

DEVELOPMENTAL BIOLOGY | 2003年 / 260卷 / 02期

关键词：

D O I：

10.1016/S0012-1606(03)00256-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first global transcriptional profile of the state of "stemness" in human embryonic stem cells (HESCs). We have identified a set of 918 genes enriched in undifferentiated HESCs compared with their differentiated counterparts. These include ligand/receptor pairs and secreted inhibitors of the FGF, TGFbeta/ssMP, and Wnt pathways, highlighting a prevalent role for these pathways in HESCs. Importantly, a significant number of HESCs-enriched genes, including several signaling components, are found to be intersected with published mouse embryonic stem cell data, indicating that a "core molecular program" is shared between the two pluripotent stem cells. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

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页码：404 / 413

页数：10

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