Dehydrogenases and transaminases in asymmetric synthesis

被引：148

作者：

Stewart, JD ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1367-5931(00)00180-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Improved stereoselectivity in dehydrogenase-mediated reductions has been achieved by rationally designed gene overexpression and knockouts in Saccharomyces cerevisiae cells and by isolating and characterizing novel dehydrogenases from other organisms. Transaminases have been used to prepare unnatural amines and amino acids in good yields. particularly when the equilibria are shifted by selective product removal.

引用

收藏

页码：120 / 129

页数：10

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