Baker's yeast reduction of α-alkyl-α-hydroxy-β-keto esters

被引：17

作者：

Buisson, D

Baucherel, X

Levoirier, E

Juge, S

机构：

[1] Univ Paris 05, CNRS, UMR 8601,Grp Metab & Biosynthese, Chim & Biochim Pharmacol & Toxicol Lab, F-75270 Paris 06, France

[2] Univ Cergy Pontoise, Unite Mixte Synthese Organ Select & Chim Organome, ESCOM, CNRS,EP 1822, F-95031 Cergy Pontoise, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 09期

关键词：

microbial reactions; resolution; hydroxy eaters; diols;

D O I：

10.1016/S0040-4039(99)02274-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic or acyclic alpha-alkyl-alpha-hydroxy-beta-keto esters were reduced by baker's yeast with high stereospecificity. In the former case, one enantiomer of the racemic mixture was transformed into optically active trans-dihydroxy compounds, while the remaining alpha-hydroxy-beta-keto ester was enantiopure. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1389 / 1392

页数：4

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