Thrombin inhibitors based on a propargylglycine template

被引：12

作者：

Lee, K ^{[1
]}

Hwang, SY ^{[1
]}

Park, CW ^{[1
]}

机构：

[1] LG Chem Ltd, Biotech Res Inst, Taejon 305380, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00125-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel arylsulfonylpropargylglycinamide derivatives was investigated as thrombin inhibitors in which the SAR was focused on substituents at the acetylenic terminus. Several compounds in this series were identified as potent thrombin inhibitors (Ki up to 5 nM) that are highly selective over trypsin and other serine proteases as well. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1013 / 1018

页数：6

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