Tough and Biocompatible Hydrogels Based on in Situ Interpenetrating Networks of Dithiol-Connected Graphene Oxide and Poly(vinyl alcohol)

被引：65

作者：

Du, Gaolai ^{[1
]}

Nie, Lei ^{[1
]}

Gao, Guorong ^{[1
]}

Sun, Yuanna ^{[1
]}

Hou, Ruixia ^{[1
]}

Zhang, Hua ^{[1
]}

Chen, Tao ^{[1
]}

Fu, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Polymers & Composites Div, Ningbo 315201, Zhejiang, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 05期

基金：

浙江省自然科学基金;

关键词：

inorganic/organic; IPN; tough; cell-adhesion; hydrogel; MECHANICAL-PROPERTIES; ORGANIZATION; DESIGN;

D O I：

10.1021/acsami.5b00184

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

An interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the efforts have been focused on organic/organic networks. Herein, aqueous dispersible 2,2'-(ethylenedioxy)-diethanethiol (EDDET) cross-linked graphene oxide (E-cGO) skeleton was in situ incorporated into a PVA matrix, resulting in novel inorganic/organic IPN hydrogels with super mechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated as being biocompatible, which make the E-cGO/PVA hydrogels promising candidate biomaterials for load-bearing biotissue substitution.

引用

页码：3003 / 3008

页数：6

共 30 条

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Bio-lnspired Borate Cross-Linking in Ultra-Stiff Graphene Oxide Thin Films [J].