Enantioselective analysis of an asymmetric reaction using a chiral fluorosensor

被引：69

作者：

Tumambac, GE ^{[1
]}

Wolf, C ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 18期

关键词：

D O I：

10.1021/ol0516216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An axially chiral 1,8-dipyridylnaphthalene N,N'-dioxide has been employed in enantioselective fluorescence analysis of the enzymatic kinetic resolution of trans-1,2-diaminocyclohexane. The procedure eliminates cumbersome purification and derivatization steps required by traditional methods. The results demonstrate the potential of fluorescence spectroscopy using suitable chiral chemosensors for real-time analysis of the enantiomeric composition of chiral compounds and for high-throughput screening of asymmetric reactions.

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页码：4045 / 4048

页数：4

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