Proton beam therapy

被引:256
作者
Levin, WP [1 ]
Kooy, H [1 ]
Loeffler, JS [1 ]
DeLaney, TF [1 ]
机构
[1] Massachusetts Gen Hosp NE, Proton Therapy Ctr, Boston, MA 02114 USA
关键词
radiotherapy; protein beam;
D O I
10.1038/sj.bjc.6602754
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.
引用
收藏
页码:849 / 854
页数:6
相关论文
共 35 条
[11]   Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas [J].
Kamada, T ;
Tsujii, H ;
Tsuji, H ;
Yanagi, T ;
Mizoe, J ;
Miyamoto, T ;
Kato, H ;
Yamada, S ;
Morita, S ;
Yoshikawa, K ;
Kandatsu, S ;
Tateishi, A .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (22) :4466-4471
[12]   Nasopharyngeal carcinoma: Repeat treatment with conformal proton therapy - Dose-volume histogram analysis [J].
Lin, R ;
Slater, JD ;
Yonemoto, LT ;
Grove, RI ;
Teichman, SL ;
Watt, DK ;
Slater, JM .
RADIOLOGY, 1999, 213 (02) :489-494
[13]   Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma [J].
Lundkvist, J ;
Ekman, M ;
Ericsson, SR ;
Jönsson, B ;
Glimelius, B .
CANCER, 2005, 103 (04) :793-801
[14]   Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: Long-term experience and prognostic factors [J].
Milker-Zabel, S ;
Zabel, A ;
Schulz-Ertner, D ;
Schlegel, W ;
Wannenmacher, M ;
Debus, J .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 61 (03) :809-816
[15]   Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors [J].
Miralbell, R ;
Lomax, A ;
Cella, L ;
Schneider, U .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 54 (03) :824-829
[16]   Proton therapy for uveal melanomas and other eye lesions [J].
Munzenrider, JE .
STRAHLENTHERAPIE UND ONKOLOGIE, 1999, 175 (Suppl 2) :68-73
[17]   Proton therapy for tumors of the skull base [J].
Munzenrider, JE ;
Liebsch, NJ .
STRAHLENTHERAPIE UND ONKOLOGIE, 1999, 175 (Suppl 2) :57-63
[18]   Relative biological effectiveness (RBE) values for proton beam therapy [J].
Paganetti, H ;
Niemierko, A ;
Ancukiewicz, M ;
Gerweck, LE ;
Goitein, M ;
Loeffler, JS ;
Suit, HD .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 53 (02) :407-421
[19]   Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of skull: Demonstration of a dose-effect relationship using dose-volume histogram analysis [J].
Pai, HH ;
Thornton, A ;
Katznelson, L ;
Finkelstein, DM ;
Adams, JA ;
Fullerton, BC ;
Loeffler, JS ;
Leibsch, NJ ;
Klibanski, A ;
Munzenrider, JE .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (04) :1079-1092
[20]   Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer [J].
Pollack, A ;
Zagars, GK ;
Smith, LG ;
Lee, JJ ;
von Eschenbach, AC ;
Antolak, JA ;
Starkschall, G ;
Rosen, I .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (23) :3904-3911