Origin of introns by "intronization' of exonic sequences

被引：69

作者：

Irimia, Manuel ^{[2
]}

Rukov, Jakob Lewin ^{[3
]}

Penny, David ^{[4
]}

Vinther, Jeppe ^{[3
]}

Garcia-Fernandez, Jordi ^{[2
]}

Roy, Scott William ^{[1
]}

机构：

[1] Natl Inst Hlth, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA

[2] Univ Barcelona, Fac Biol, Dept Genet, E-08028 Barcelona, Spain

[3] Univ Copenhagen, Dept Biol, Mol Evolut Grp, DK-2200 Copenhagen, Denmark

[4] Massey Univ, Allan Wilson Ctr Mol Evolut & Ecol, Palmerston North, New Zealand

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 08期

关键词：

D O I：

10.1016/j.tig.2008.05.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron creation in nematodes. Intronization is more common than the reverse process, loss of splicing of retained introns. Finally, these findings link alternative splicing with modern intron creation.

引用

页码：378 / 381

页数：4

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