Tumor necrosis factor: An apoptosis JuNKie?

被引：424

作者：

Varfolomeev, EE ^{[1
]}

Ashkenazi, A ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

CELL | 2004年 / 116卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(04)00166-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

引用

页码：491 / 497

页数：7

共 32 条

[1] Cell signalling (communication arising) - Cell survival and a Gadd45-factor deficiency
Amanullah, A
Azam, N
Balliet, A
Hollander, C
Hoffman, B
Fornace, A
Liebermann, D
[J]. NATURE, 2003, 424 (6950) : 741 - 742
[2] Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Ashkenazi, A
[J]. NATURE REVIEWS CANCER, 2002, 2 (06) : 420 - 430
[3] A physical and functional map of the human TNF-α NF-κB signal transduction pathway
Bouwmeester, T
Bauch, A
Ruffner, H
Angrand, PO
Bergamini, G
Croughton, K
Cruciat, C
Eberhard, D
Gagneur, J
Ghidelli, S
Hopf, C
Huhse, B
Mangano, R
Michon, AM
Schirle, M
Schlegl, J
Schwab, M
Stein, MA
Bauer, A
Casari, G
Drewes, G
Gavin, AC
Jackson, DB
Joberty, G
Neubauer, G
Rick, J
Kuster, B
Superti-Furga, G
[J]. NATURE CELL BIOLOGY, 2004, 6 (02) : 97 - +
[4] TNF-R1 signaling: A beautiful pathway
Chen, GQ
Goeddel, DV
[J]. SCIENCE, 2002, 296 (5573) : 1634 - 1635
[5] The BCL2 family: Regulators of the cellular life-or-death switch
Cory, S
Adams, JM
[J]. NATURE REVIEWS CANCER, 2002, 2 (09) : 647 - 656
[6] A JNK-dependent pathway is required for TNFα-induced apoptosis
Deng, YB
Ren, XY
Yang, L
Lin, YH
Wu, XW
[J]. CELL, 2003, 115 (01) : 61 - 70
[7] DIETRICH N, 2003, IN PRESS CELL DEATH
[8] Characterization of XIAP-deficient mice
Harlin, H
Reffey, SB
Duckett, CS
Lindsten, T
Thompson, CB
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (10) : 3604 - 3608
[9] Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
Igaki, T
Kanda, H
Yamamoto-Goto, Y
Kanuka, H
Kuranaga, E
Aigaki, T
Miura, M
[J]. EMBO JOURNAL, 2002, 21 (12) : 3009 - 3018
[10] Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling
Kanda, H
Igaki, T
Kanuka, H
Yagi, T
Miura, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) : 28372 - 28375

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