Phosphono peptide nucleic acids with a constrained hydroxyproline-based backbone

被引：12

作者：

Efimov, VA ^{[1
]}

Klykov, VN ^{[1
]}

Chakhmakhcheva, OG ^{[1
]}

机构：

[1] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

DNA mimics; phosphono-PNAs; trans-4-hydroxy-L-proline; derivatives;

D O I：

10.1081/NCN-120021962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA mimics representing negatively charged analogues of peptide nucleic acids (PNAs), particularly hetero-oligomers constructed from alternating phosphono-PNA residues (pPNA) and monomers on the base of trans-4-hydroxy-L-proline (HypNA) as well as mimics composed of phosphono-HypNA monomers (pHypNA) were tested in a set of in vitro and in vivo assays, and they demonstrated a high potential for the use in nucleic acid based diagnostic, isolation of nucleic acids and antisense experiments.

引用

页码：593 / 599

页数：7

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