Functional relevance of miRNA* sequences in human disease

被引：65

作者：

Bhayani, Mihir K.

Calin, George A. ^{[2
]}

Lai, Stephen Y. ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 1445, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2012年 / 731卷 / 1-2期

关键词：

microRNA; microRNA*; microRNA star; microRNA strand selection; RNA interference; RNA induced silencing complex; MICRORNA BIOGENESIS; RNA INTERFERENCE; STRAND SELECTION; GUIDE STRAND; EXPRESSION; GENE; MIR-126-ASTERISK; PROGNOSIS; EVOLUTION; CLEAVAGE;

D O I：

10.1016/j.mrfmmm.2011.10.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MicroRNA (miRNA) processing in the cytoplasm produces a miRNA duplex containing the forward, miRNA strand and the reverse, miRNA* strand, which was thought to be degraded. However, recent evidence is challenging this dogma that miRNA* is simply a non-functional byproduct of miRNA biogenesis. We present a comprehensive review of evidence that miRNA* plays a significant role in cellular function and assembled a table outlining all of the publications before September 2011 that have reported on miRNA* activity in human disease. Furthermore, we will present unexpected diagnostic and therapeutic implications due to the active miRNA* status. (C) 2011 Elsevier B.V. All rights reserved.

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收藏

页码：14 / 19

页数：6

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