Cp*RuCl-catalyzed formal intermolecular cyclotrimerization of three unsymmetrical alkynes through a boron temporary tether: Regioselective four-component coupling synthesis of phthalides

被引：148

作者：

Yamamoto, Y ^{[1
]}

Ishii, J ^{[1
]}

Nishiyama, H ^{[1
]}

Itoh, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Appl Chem, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 26期

关键词：

D O I：

10.1021/ja051377d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly substituted phthalides were efficiently synthesized by sequential Cp*RuCl-catalyzed cyclotrimerization of alkynylboronates, propargyl alcohols, and terminal alkynes and palladium(II)-catalyzed carbonylation of the resultant arylboronates. The intermediate arylboronate was isolated and unambiguously characterized by X-ray crystallography. The perfect regioselectivity of the ruthenium-catalyzed formal intermolecular cyclotrimerization was discussed on the basis of the density functional calculations of a boraruthenacycle intermediate.

引用

页码：9625 / 9631

页数：7

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