Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs

被引：378

作者：

Ashammakhi, N. ^{[1
,2
,3
]}

Ahadian, S. ^{[1
,2
]}

Xu, C. ^{[1
,2
,4
]}

Montazerian, H. ^{[1
,2
]}

Ko, H. ^{[1
,2
]}

Nasiri, R. ^{[1
,2
,5
]}

Barros, N. ^{[1
,2
]}

Khademhosseini, A. ^{[1
,2
,6
,7
]}

机构：

[1] Univ Calif Los Angeles, Ctr Minimally Invas Therapeut C MIT, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[3] Oulu Univ, Div Plast Surg, Dept Surg, Oulu 8000, Finland

[4] Univ Queensland, Sch Dent, Herston, Qld 4006, Australia

[5] Sharif Univ Technol, Dept Mech Engn, Tehran 1136511155, Iran

[6] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

来源：

MATERIALS TODAY BIO | 2019年 / 1卷

基金：

美国国家卫生研究院;

关键词：

Three-dimensional bioprinting; Biofabrication; Regenerative medicine; Tissue engineering; BONE MORPHOGENETIC PROTEIN-2; BETA-TRICALCIUM-PHOSPHATE; MESENCHYMAL STEM-CELLS; SILK FIBROIN; BIOACTIVE GLASS; IN-VITRO; PHOTOCROSSLINKABLE HYALURONAN; MECHANICAL-PROPERTIES; COMPOSITE HYDROGEL; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.mtbio.2019.100008

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The native tissues are complex structures consisting of different cell types, extracellular matrix materials, and biomolecules. Traditional tissue engineering strategies have not been able to fully reproduce biomimetic and heterogeneous tissue constructs because of the lack of appropriate biomaterials and technologies. However, recently developed three-dimensional bioprinting techniques can be leveraged to produce biomimetic and complex tissue structures. To achieve this, multicomponent bioinks composed of multiple biomaterials (natural, synthetic, or hybrid natural-synthetic biomaterials), different types of cells, and soluble factors have been developed. In addition, advanced bioprinting technologies have enabled us to print multimaterial bioinks with spatial and microscale resolution in a rapid and continuous manner, aiming to reproduce the complex architecture of the native tissues. This review highlights important advances in heterogeneous bioinks and bioprinting technologies to fabricate biomimetic tissue constructs. Opportunities and challenges to further accelerate this research area are also described.

引用

页数：23

共 261 条

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A Synthetic Thermosensitive Hydrogel for Cartilage Bioprinting and Its Biofunctionalization with Polysaccharides [J].