Control of bacterial transcription, translation and replication by (p)ppGpp

被引：295

作者：

Srivatsan, Anjana ^{[1
]}

Wang, Jue D. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1016/j.mib.2008.02.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes ReIA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by ReIA and two small homologs. (p)ppGpp, along with the transcription factor DksA, has profound effects on transcription initiation in E coli. (p)ppGpp/DksA exert differential effects on promoters by playing upon their intrinsic kinetic parameters, and by facilitating the utilization of alternative sigma factors. (p)ppGpp also regulates replication and translation. These studies highlight (p)ppGpp as a key factor in bacterial physiology that responds rapidly to diverse stresses, by shutting down growth and priming cellular defensive and adaptive processes.

引用

页码：100 / 105

页数：6

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