Natural killer cell activities of synbiotic Lactobacillus casei ssp casei in conjunction with dextran

被引：51

作者：

Ogawa, T ^{[1
]}

Asai, Y ^{[1
]}

Tamai, R ^{[1
]}

Makimura, Y ^{[1
]}

Sakamoto, H ^{[1
]}

Hashikawa, S ^{[1
]}

Yasuda, K ^{[1
]}

机构：

[1] Asahi Univ, Sch Dent, Dept Oral Microbiol, Mizuho Ku, Gifu 5010296, Japan

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2006年 / 143卷 / 01期

关键词：

cytokine; dextran; Lactobacillus casei ssp; casei; natural killer; synbiotic;

D O I：

10.1111/j.1365-2249.2005.02975.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have reported previously that Lactobacillus casei ssp. casei, together with specific substrate dextran, exhibited an adjuvant effect of stimulating humoral immune responses against bovine serum albumin (BSA) as a model antigen in BALB/c mice. In the present study, among the Lactobacillus species tested, L. casei ssp. casei with dextran significantly elevated the natural killer (NK) cell activites in spleen mononuclear cells from BALB/c mice in comparison to L. casei ssp. casei alone or other Lactobacillus species with or without dextran. Oral administration of L. casei ssp. casei together with dextran also resulted in a significant increase of NK cell activities in healthy human volunteers. Further, L. casei ssp. casei induced significant production of interleukin (IL)-12 in human peripheral blood mononuclear cells and IL-15 mRNA expression in the human intestinal epithelial cell line Caco-2. L. casei ssp. casei with dextran in food also significantly elevated the survival rate of BALB/c mice bearing Meth-A cells. Taken together, these results demonstrate that dietary synbiotic supplementation which is a combination of the L. casei ssp. casei used as a probiotic together with the dextran, a specific substrate as a prebiotic, efficiently elicits murine and human NK cell activities.

引用

页码：103 / 109

页数：7