Bringing chemistry to life

被引：170

作者：

Boyce, Michael ^{[1
]}

Bertozzi, Carolyn R. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

NATURE METHODS | 2011年 / 8卷 / 08期

基金：

美国国家卫生研究院;

关键词：

FREE CLICK CHEMISTRY; NEWLY SYNTHESIZED PROTEINS; IN-VIVO; STAUDINGER LIGATION; CELL-SURFACES; 1,3-DIPOLAR CYCLOADDITIONS; DEVELOPING ZEBRAFISH; TERMINAL ALKYNES; LIVING ANIMALS; AZIDES;

D O I：

10.1038/nmeth.1657

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioorthogonal chemistry allows a wide variety of biomolecules to be specifically labeled and probed in living cells and whole organisms. Here we discuss the history of bioorthogonal reactions and some of the most interesting and important advances in the field.

引用

页码：638 / 642

页数：5

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