The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

被引：278

作者：

Auffinger, Brenda ^{[1
]}

Spencer, Drew ^{[1
]}

Pytel, Peter ^{[1
]}

Ahmed, Atique U. ^{[1
]}

Lesniak, Maciej S. ^{[1
]}

机构：

[1] Univ Chicago, Brain Tumor Ctr, Chicago, IL 60637 USA

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 07期

关键词：

chemoresistance; glioma stem cells; malignant glioma; mechanisms; plasticity recurrence; TUMOR-INITIATING CELLS; TYROSINE KINASE GENES; SIDE POPULATION; MULTIDRUG-RESISTANCE; CLONAL EVOLUTION; DRUG-RESISTANCE; SELF-RENEWAL; DNA-REPAIR; TEMOZOLOMIDE; BRAIN;

D O I：

10.1586/14737175.2015.1051968

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Glioma stem cells (GSCs) constitute a slow-dividing, small population within a heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole tumor, and differentiate into other specific glioblastoma multiforme (GBM) subpopulations. Therefore, they have been held responsible for malignant relapse after primary standard therapy and the poor prognosis of recurrent GBM. The failure of current therapies to eliminate specific GSC subpopulations has been considered a major factor contributing to the inevitable recurrence in GBM patients after treatment. Here, we discuss the molecular mechanisms of chemoresistance of GSCs and the reasons why complete eradication of GSCs is so difficult to achieve. We will also describe the targeted therapies currently available for GSCs and possible mechanisms to overcome such chemoresistance and avoid therapeutic relapse.

引用

页码：741 / 752

页数：12

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