The rise and fall of genomic methylation in cancer

被引：27

作者：

El-Osta, A ^{[1
]}

机构：

[1] Baker Med Res Inst, AMREP, Epigenet Human Hlth & Dis Lab, Prahran, Vic 3181, Australia

来源：

LEUKEMIA | 2004年 / 18卷 / 02期

关键词：

cancer; epigenetics; histones; methylation; methyltransferases; mice knockouts;

D O I：

10.1038/sj.leu.2403218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so far that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.

引用

页码：233 / 237

页数：5

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