Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives

被引：159

作者：

Arshad, Afsheen ^{[1
]}

Osman, Hasnah ^{[1
]}

Bagley, Mark C. ^{[2
]}

Lam, Chan Kit ^{[3
]}

Mohamad, Suriyati ^{[4
]}

Zahariluddin, Anis Safirah Mohd ^{[4
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia

[2] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

[3] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

[4] Univ Sains Malaysia, Sch Biol Sci, George Town 11800, Malaysia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 09期

关键词：

Hydrazinyl thiazolyl coumarins; Antimicrobial activity; Mycobacterium tuberculosis; TRANSITION-METAL-COMPLEXES; ANTITUMOR-ACTIVITY; 2,4-DISUBSTITUTED THIAZOLES; INHIBITORS; AGENTS; ANTIBACTERIAL; BENZYLIDENEHYDRAZONES; POTENT;

D O I：

10.1016/j.ejmech.2011.05.044

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, H-1 NMR, C-13 NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：3788 / 3794

页数：7

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