DDQ-promoted dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones by a radical ion mechanism

被引：23

作者：

Ding, Ye ^{[1
]}

Huang, Zhangjian ^{[1
]}

Yin, Jian ^{[1
]}

Lai, Yisheng ^{[1
]}

Zhang, Shibo ^{[1
]}

Zhang, Zhiguo ^{[1
]}

Fang, Lei ^{[1
]}

Peng, Sixun ^{[1
]}

Zhang, Yihua ^{[1
]}

机构：

[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 33期

关键词：

OXIDE-RELEASING DERIVATIVES; OLEANOLIC ACID; TRITERPENOIDS; CANCER;

D O I：

10.1039/c1cc11633a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel and facile DDQ-mediated dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones is described. The formation of lactones proceeds by a radical ion mechanism, which has been established by DPPH(center dot)-mediated chemical identification, ESR spectroscopy and an enol intermediate trapping.

引用

收藏

页码：9495 / 9497

页数：3

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