Prospects for prevention and treatment of cancer with selective PPARγmodulators (SPARMs)

被引：133

作者：

Sporn, MB ^{[1
]}

Suh, N

Mangelsdorf, DJ

机构：

[1] Dartmouth Coll Sch Med, Dept Pharmacol, Hanover, NH 03755 USA

[2] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1471-4914(01)02100-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator-activated receptor gamma (PPAR gamma), a nuclear receptor and transcription factor that regulates the expression of many genes relevant to carcinogenesis, is now an important target for development of new drugs for the prevention and treatment of cancer. Deficient expression of PPAR gamma can be a significant risk factor for carcinogenesis, although in some cases overexpression enhances carcinogenesis. Ligands for PPAR gamma suppress breast carcinogenesis in experimental models and induce differentiation of human liposarcoma cells. By analogy to the selective estrogen receptor modulator (SERM) concept, it is suggested that selective PPAR gamma modulators (SPARMs), designed to have desired effects on specific genes and target tissues without undesirable effects on others, will be clinically important in the future for chemoprevention and chemotherapy of cancer.

引用

页码：395 / 400

页数：6

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