Stereospecific Substitution of Allylic Alcohols To Give Optically Active Primary Allylic Amines: Unique Reactivity of a (P,alkene)Ir Complex Modulated by Iodide

被引：145

作者：

Roggen, Markus ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 34期

关键词：

ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC CATALYSIS; AMINATION; LIGANDS; PHOSPHORAMIDITE; ALKYLATION; RHODIUM; ESTERS; REGIOSELECTIVITY; HYDROGENATION;

D O I：

10.1021/ja105271z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stereospecific allylic amination of unactivated secondary (2 degrees)-allylic alcohols is reported. The primary (1 degrees)-allylic amine can be isolated directly or protected in situ. Spectroscopic studies have shed light on the structure of the catalytically active Ir.(P,olefin)2I complex.

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收藏

页码：11917 / 11919

页数：3

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