Growth and division-not a one-way road

被引：34

作者：

Goranov, Alexi I.

Amon, Angelika ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 06期

关键词：

YEAST SCHIZOSACCHAROMYCES-POMBE; CELL-CYCLE; SACCHAROMYCES-CEREVISIAE; FISSION YEAST; RIBOSOME SYNTHESIS; SINGLE CELLS; SIZE CONTROL; PROTEIN; RNA; PATHWAY;

D O I：

10.1016/j.ceb.2010.06.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Maintaining cell size homeostasis and regulating cell size in response to changing conditions is a fundamental property of organisms. Here we examine the recent advances in our understanding of the interplay between accumulation of mass (growth) and the progression through the cell cycle (proliferation), the coordination of which determines the size of cells. It is well established that growth affects cell division (reviewed in Jorgensen and Tyers, 2004 [1]). This review will focus on the reverse, less well-defined relationship - how cell cycle progression affects growth. We will summarize findings that indicate that growth is not constant during the cell cycle and discuss the surprising possibility that cyclin-dependent kinases (CDKs) inhibit growth.

引用

页码：795 / 800

页数：6

共 46 条

[1] BUOYANT DENSITY VARIATION DURING THE CELL-CYCLE OF SACCHAROMYCES-CEREVISIAE [J].