In utero programming of chronic disease

被引：1202

作者：

Barker, DJP ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England

来源：

CLINICAL SCIENCE | 1998年 / 95卷 / 02期

关键词：

coronary heart disease; diabetes; fetus; hypertension; programming; undernutrition;

D O I：

10.1042/CS19980019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

引用

页码：115 / 128

页数：14

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