In utero programming of chronic disease

被引：1202

作者：

Barker, DJP ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England

来源：

CLINICAL SCIENCE | 1998年 / 95卷 / 02期

关键词：

coronary heart disease; diabetes; fetus; hypertension; programming; undernutrition;

D O I：

10.1042/CS19980019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

引用

页码：115 / 128

页数：14

共 124 条

[81] DIFFERENCES IN THE PREVALENCE OF DIABETES AND IMPAIRED GLUCOSE-TOLERANCE ACCORDING TO MATERNAL OR PATERNAL HISTORY OF DIABETES [J].

MITCHELL, BD ;

VALDEZ, R ;

HAZUDA, HP ;

HAFFNER, SM ;

MONTERROSA, A ;

STERN, MP .

DIABETES CARE, 1993, 16 (09) :1262-1267

[82] Placental weight, birth measurements, and blood pressure at age 8 years [J].

Moore, VM ;

Miller, AG ;

Boulton, TJC ;

Cockington, RA ;

Craig, IH ;

Magarey, AM ;

Robinson, JS .

ARCHIVES OF DISEASE IN CHILDHOOD, 1996, 74 (06) :538-541

[83] Chronic fetal placental embolization and hypoxemia cause hypertension and myocardial hypertrophy in fetal sheep [J].

Murotsuki, J ;

Challis, JRG ;

Han, VKM ;

Fraher, LJ ;

Gagnon, R .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 272 (01) :R201-R207

[84]

None, 1996, AM J HYPERTENS, V9, p11A

[85]

Olah K. S., 1996, Journal of Obstetrics and Gynaecology (Abingdon), V16, P5, DOI 10.3109/01443619609028371

[86] GLUCOSE BUT NOT A MIXED AMINO-ACID INFUSION REGULATES PLASMA INSULIN-LIKE GROWTH FACTOR-I CONCENTRATIONS IN FETAL SHEEP [J].

OLIVER, MH ;

HARDING, JE ;

BREIER, BH ;

EVANS, PC ;

GLUCKMAN, PD .

PEDIATRIC RESEARCH, 1993, 34 (01) :62-65

[87] EARLY GROWTH AND DEATH FROM CARDIOVASCULAR-DISEASE IN WOMEN [J].

OSMOND, C ;

BARKER, DJP ;

WINTER, PD ;

FALL, CHD ;

SIMMONDS, SJ .

BRITISH MEDICAL JOURNAL, 1993, 307 (6918) :1519-1524

[88] EARLY ORIGIN OF CORONARY HEART-DISEASE (THE BARKER HYPOTHESIS) [J].

PANETH, N ;

SUSSER, M .

BRITISH MEDICAL JOURNAL, 1995, 310 (6977) :411-412

[89]

Phillips DIW, 1997, DIABETIC MED, V14, P673, DOI 10.1002/(SICI)1096-9136(199708)14:8<673::AID-DIA458>3.0.CO

[90]

2-9

← 4 5 6 7 8 9 10 11 12 13 →