Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

被引：67

作者：

Yang, Jaemoon

Lee, Tong-Il

Lee, Jaemin

Lim, Eun-Kyung

Hyung, Woochan

Lee, Choong-Hwan

Song, Yong Jin

Suh, Jin-Suck

Yoon, Ho-Geun

Huh, Yong-Min ^{[1
]}

Haam, Seungjoo

机构：

[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Ctr Chron Metab Dis Res, Dept Biochem & Mol Biol, Seoul 120752, South Korea

[3] Yonsei Univ, Coll Engn, Dept Chem Engn, Seoul 120749, South Korea

[4] ATGen, Adv Technol Res Ctr, Gyeonggi Do 463816, South Korea

[5] Ajou Univ, Coll Nat Sci, Dept Phys, Suwon 433749, South Korea

来源：

CHEMISTRY OF MATERIALS | 2007年 / 19卷 / 16期

关键词：

D O I：

10.1021/cm070495s

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

引用

页码：3870 / 3876

页数：7

共 27 条

[11] PEGylation of liposome decreases the susceptibility of liposomal drug in cancer photodynamic therapy [J].