The centromere paradox: Stable inheritance with rapidly evolving DNA

被引：967

作者：

Henikoff, S ^{[1
]}

Ahmad, K ^{[1
]}

Malik, HS ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Res Labs, Seattle, WA 98109 USA

来源：

SCIENCE | 2001年 / 293卷 / 5532期

关键词：

D O I：

10.1126/science.1062939

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across at[ eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.

引用

页码：1098 / 1102

页数：5

共 88 条

[1] A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation [J].

Agudo, M ;

Abad, JP ;

Molina, I ;

Losada, A ;

Ripoll, P ;

Villasante, A .

CHROMOSOMA, 2000, 109 (03) :190-196

[2] Centromeres are specialized replication domains in heterochromatin [J].

Ahmad, K ;

Henikoff, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :101-109

[3]

BUCHWITZ B, UNPUB

[4] Cell division -: A histone-H3-like protein in C-elegans [J].

Buchwitz, BJ ;

Ahmad, K ;

Moore, LL ;

Roth, MB ;

Henikoff, S .

NATURE, 1999, 401 (6753) :547-548

[5]

Buckler ES, 1999, GENETICS, V153, P415

[6] Structure of the chromosome VII centromere region in neurospora crassa: Degenerate transposons and simple repeats [J].

Cambareri, EB ;

Aisner, R ;

Carbon, J .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (09) :5465-5477

[7] THE EVOLUTIONARY DYNAMICS OF REPETITIVE DNA IN EUKARYOTES [J].

CHARLESWORTH, B ;

SNIEGOWSKI, P ;

STEPHAN, W .

NATURE, 1994, 371 (6494) :215-220

[8] Centromerization [J].

Choo, KHA .

TRENDS IN CELL BIOLOGY, 2000, 10 (05) :182-188

[9] The evolutionary genetics of speciation [J].

Coyne, JA ;

Orr, HA .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1998, 353 (1366) :287-305

[10] Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression [J].

Craig, JM ;

Earnshaw, WC ;

Vagnarelli, P .

EXPERIMENTAL CELL RESEARCH, 1999, 246 (02) :249-262

← 1 2 3 4 5 6 7 8 9 →