Endothelial fluid shear stress sensing in vasculr health and disease

被引：430

作者：

Baeyens, Nicolas ^{[1
]}

Bandyopadhyay, Chirosree ^{[1
]}

Coon, Brian G. ^{[1
]}

Yun, Sanguk ^{[1
]}

Schwartz, Martin A. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Yale Cardiovasc Res Ctr, Dept Med Cardiol, New Haven, CT USA

[2] Yale Univ, Dept Cell Biol, New Haven, CT USA

[3] Yale Univ, Dept Biomed Engn, New Haven, CT USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2016年 / 126卷 / 03期

关键词：

CEREBRAL CAVERNOUS MALFORMATIONS; NF-KAPPA-B; CORONARY COLLATERAL CIRCULATION; RANDOMIZED CONTROLLED-TRIAL; IN-VIVO; NITRIC-OXIDE; ATHEROSCLEROSIS PROGRESSION; EXTERNAL COUNTERPULSATION; REDUCES ATHEROSCLEROSIS; MECHANOSENSORY COMPLEX;

D O I：

10.1172/JCI83083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This Review covers recent advances in basic mechanisms of flow signaling and the involvement of these mechanisms in vascular physiology, remodeling, and these diseases. We propose that flow sensing pathways that govern normal morphogenesis can contribute to disease under pathological conditions or can be altered to induce disease. Viewing atherosclerosis and vascular malformations as instances of pathological morphogenesis provides a unifying perspective that may aid in developing new therapies.

引用

收藏

页码：821 / 828

页数：8

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