Successful booster antibody response up to 54 months after single primary vaccination with virosome-formulated, aluminum-free hepatitis A vaccine

被引：15

作者：

Beck, BR

Hatz, C

Brönnimann, R

Herzog, C

机构：

[1] Swiss Trop Inst, CH-4002 Basel, Switzerland

[2] Berna Biotech, Bern, Switzerland

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 09期

关键词：

D O I：

10.1086/378890

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

This study demonstrates that a booster dose of the virosome-formulated, aluminum-free hepatitis A vaccine Epaxal (Berna Biotech) is highly immunogenic in subjects who received a single primary dose of this vaccine 18-54 months earlier. There were no significant differences in geometric mean antibody titers (GMTs) among subjects who received the booster dose 18-29 months (GMT, 2330 mIU/mL), 30-41 months (GMT, 2395 mIU/mL), or 42-54 months (GMT, 2432 mIU/mL) after primary vaccination, indicating that delays in the administration of booster vaccination do not lead to a loss of immunogenicity.

引用

收藏

页码：E126 / E128

页数：3

相关论文

共 14 条

[1]

Immunogenicity and protectivity of a new liposomal hepatitis A vaccine [J].

Ambrosch, F ;

Wiedermann, G ;

Jonas, S ;

Althaus, B ;

Finkel, B ;

Gluck, R ;

Herzog, C .

VACCINE, 1997, 15 (11) :1209-1213

[2]

[Anonymous], 2000, Wkly Epidemiol Rec, V75, P38

[3]

Tolerance and immunogenicity of the simultaneous administration of virosome hepatitis A and yellow fever vaccines [J].

Bovier, PA ;

Althaus, B ;

Glueck, R ;

Chippaux, A ;

Loutan, L .

JOURNAL OF TRAVEL MEDICINE, 1999, 6 (04) :228-233

[4]

Hepatitis A: Old and new [J].

Cuthbert, JA .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (01) :38-+

[5]

Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: A randomized controlled trial [J].

Holzer, BR ;

Hatz, C ;

SchmidtSissolak, D ;

Gluck, R ;

Althaus, B ;

Egger, M .

VACCINE, 1996, 14 (10) :982-986

[6]

Excellent booster response 4-6 y after a single primary dose of an inactivated hepatitis A vaccine [J].

Iwarson, S ;

Lindh, M ;

Widerström, L .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2002, 34 (02) :110-111

[7]

A SINGLE VACCINATION WITH AN INACTIVATED HEPATITIS-A LIPOSOME VACCINE INDUCES PROTECTIVE ANTIBODIES AFTER ONLY 2 WEEKS [J].

JUST, M ;

BERGER, R ;

DRECHSLER, H ;

BRANTSCHEN, S ;

GLUCK, R .

VACCINE, 1992, 10 (11) :737-739

[8]

Hepatitis A [J].

Koff, RS .

LANCET, 1998, 351 (9116) :1643-1649

[9]

Inactivated hepatitis A vaccine booster given ≥24 months after the primary dose [J].

Landry, P ;

Tremblay, S ;

Darioli, R ;

Genton, B .

VACCINE, 2000, 19 (4-5) :399-402

[10]

INACTIVATED VIROSOME HEPATITIS-A VACCINE [J].

LOUTAN, L ;

BOVIER, P ;

ALTHAUS, B ;

GLUCK, R .

LANCET, 1994, 343 (8893) :322-324