Immunoglobulin Responses at the Mucosal Interface

被引:261
作者
Cerutti, Andrea [1 ,2 ,3 ]
Chen, Kang [3 ]
Chorny, Alejo [3 ]
机构
[1] Hosp del Mar, ICREA, Catalan Inst Res & Adv Studies, Barcelona 08003, Spain
[2] Hosp del Mar, Municipal Inst Med Res, Barcelona 08003, Spain
[3] Mt Sinai Sch Med, Dept Med, Inst Immunol, New York, NY 10029 USA
来源
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 | 2011年 / 29卷
关键词
mucosal immunity; B cells; IgA; IgD; class switching; CLASS-SWITCH RECOMBINATION; PROPRIA DENDRITIC CELLS; COMMON VARIABLE IMMUNODEFICIENCY; POLYMERIC IG RECEPTOR; HUMAN B-CELLS; T-CELL; EPITHELIAL-CELLS; LYMPHOID-TISSUE; GERMINAL CENTER; PEYERS-PATCH;
D O I
10.1146/annurev-immunol-031210-101317
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mucosal surfaces are colonized by large communities of commensal bacteria and represent the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B cells release large amounts of immunoglobulin (Ig) molecules through multiple follicular and extrafollicular pathways. IgA is the most abundant antibody isotype in mucosal secretions and owes its success in frontline immunity to its ability to undergo transcytosis across epithelial cells. In addition to translocating IgA onto the mucosal surface, epithelial cells educate the mucosal immune system as to the composition of the local microbiota and instruct B cells to initiate IgA responses that generate immune protection while preserving immune homeostasis. Here we review recent advances in our understanding of the cellular interactions and signaling pathways governing IgA production at mucosal surfaces and discuss new findings on the regulation and function of mucosal IgD, the most enigmatic isotype of our mucosal antibody repertoire.
引用
收藏
页码:273 / 293
页数:21
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